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The Flexeril is taken at bedtime to help me get to and stay asleep. What is the difference between carisoprodol and cyclobenzaprine hydrochloride? Sometimes muscles spasms what’s the difference between carisoprodol and flexeril the neck can cause headaches. This medication is intended to be used for only two or three weeks at a time. Try… Read More: What's the difference between carisoprodol and flexeril »